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Communication | Regular issue | Vol 6, No. 5, 1977, pp.529-533
Published online, 1st January, 1970
DOI: 10.3987/R-1977-05-0529
A Facile Synthesis of 1-(2-Tetrahydrofuryl)-5-fluorouracil (Ftorafur)

Tetsuji Kametani,* Kazuo Kigasawa, Mineharu Hiiragi, Kikuo Wakisaka, Osamu Kusama, Hideo Sugi, and Kumeo Kawasaki

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

1- (2-Tetrahydrofuryl)-5-fluorouracil (1), a potent anti-tumor agent, was conveniently synthesized by the the condensation of 5-fluorouracil (2) with various 2-alkoxy-2,3,4,5-tetrahydrofurans (3a-j), and the best yield of 1 by this method was obtained in the reaction of 2-t-butoxy analog (3h).