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Communication | Regular issue | Vol 6, No. 5, 1977, pp.525-528
Published online, 1st January, 1970
DOI: 10.3987/R-1977-05-0525
Studies on Pyrimidine Derivatives. IV. Synthesis of Hydroxymethylpyrimidines by Means of the Homolytic Hydroxymethylation

Takao Sakamoto, Kazuko Konno, Takayasu Ono, and Hiroshi Yamanaka*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

2-Hydroxymethyl- and 4-hydroxymethyl-pyrimidines were synthesized in yield ranging from 28 to 93% by the reactions of some simple pyrimidine derivatives with the hydroxymethyl radical generated from methanol and ammonium peroxydisulfate.