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Communication | Regular issue | Vol 6, No. 4, 1977, pp.415-421
Published online, 1st January, 1970
DOI: 10.3987/R-1977-04-0415
Biotransformation of Reticuline into Morphinandienone, Aporphine, and Protoberbaerine Alkaloids with Rat Liver Enzyme

Tetsuji Kametani,* Yohko Ohta, Makoto Takemura, Masataka Ihara, and Keiichiro Fukumoto

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


(±)-Reticuline (1a) was biotransformed into morphinandienone alkaloid, pallidine (4a), and aporphine alkaloid, isoboldine (5a) in addition to protoberberine alkaloids, coreximine (3a) and scoulerine (2a). The transformation was stimulated by the presence of the following cofactors, NAD, NADP or NADPH. Deuterium labelled experiment revealed that the N-methyl group of (±)-reticuline was not intactly incorporated into protoberberines.