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Communication | Regular issue | Vol 6, No. 3, 1977, pp.297-304
Published online, 1st January, 1970
DOI: 10.3987/R-1977-03-0297
Studies on the Synthesis of Bisindole Alkaloids. VIII. The Coupling of Several 3α,4α-Substituted Catharanthine Derivatives with Vindoline

James P. Kutney,* Alummoottil V. Joshua, and Ping-huang Liao

*Department of Chemisry, University of British Columbia, Vancouver 8, V5T 1W5, Canada

Abstract

A detailed study involving the Polonovski-type coupling of vindoline with 4α-hydroxydihydrocatharanthinic acid lactone (1) and 3α,4α-epoxydihydrocatharanthine (9), two catharanthine derivatives prepared earlier in our laboratories, is described.