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Communication | Regular issue | Vol 6, No. 3, 1977, pp.291-296
Published online, 1st January, 1970
DOI: 10.3987/R-1977-03-0291
The Modified Polonovski Reaction of Catharanthine Lactone N-Oxide for Coupling with Vindoline

Yasushi Honma and Yoshio Ban*

*Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan


For synthesis of bisindole alkaloids of vinblastine type, catharanthine lactone N-oxide (2) was submitted to the modified Polonovski reaction for coupling with vindoline according to Potier’s method. The products were proved to be 5 as a main product, 6 and the other one of an uncertain structure as by-products.