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Communication | Regular issue | Vol 6, No. 3, 1977, pp.285-290
Published online, 1st January, 1970
DOI: 10.3987/R-1977-03-0285
A Stereoselective Synthesis of Oxygenated Catharanthine Derivatives. Possible Precurors for Bisindole Alkaloids

Yasushi Honma and Yoshio Ban*

*Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan

Abstract

In order to synthesize the bisindole alkaloids (Ia,b) of vinblastine type, catharanthine (IIa) was converted to the lactones (IIIa,b,c) and the epoxy derivatives (IVa,b), which would be available as the precursors for the synthesis of the above natural alkaloids.