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Communication | Regular issue | Vol 6, No. 3, 1977, pp.255-260
Published online, 1st January, 1970
DOI: 10.3987/R-1977-03-0255
A Novel and Simple Synthesis of 1,3-Benzoxazin-4-one Derivatives

Tetsuji Kametani,* Terumi Higa, Chu Van Loc, Masataka Ihara, and Keiichiro Fukumoto

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


Treatment of salicyl chloride (6) with 3,4-dihydro-β-carboline (7) gave indolo[21,31:3,4]pyrido[2,l-b][1,3]benzoxazin-4-one (9), which was also obtained by a reaction of with N-formyltryptamine (8). The same reaction of 6 with 3,4-dihydro-6,7-dimethoxy-1-methylisoquinoline (11) and isoquinoline (13) afforded the corresponding pyridobenzoxazinones (12) and (14), respectively.