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Report | Regular issue | Vol 6, No. 2, 1977, pp.137-142
Published online, 1st January, 1970
DOI: 10.3987/R-1977-02-0137
The Reaction of 1,2-Diamines with a 2,3-Dioxopyrrolidines as an Approach to Pyrrolo[2,3-b]pyrazines

Stewart W. Schneller* and Jung-Hui Sun

*Department of Chemistry, University of South Florida, Tampa, Florida 33620, U.S.A.


The reaction of 1-benzyl-2,3-dioxopyrrolidine with aromatic dimnines as a means of preparing polycyclic molecules containing the pyrrolo[2,3-b]pyrazine moiety has been studied as a model route to molecules isomeric with the biologically active pyrrolo[2,3-d]pyrimidines. The spiro derivatives 17-19, however, have been the realized products rather than the desired linear systems (e.g., 9).