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Communication | Regular issue | Vol 6, No. 1, 1977, pp.25-28
Published online, 1st January, 1970
DOI: 10.3987/R-1977-01-0025
Oxidative Cyclization of 6-(N-Alkylanilino)-5-aminouracils to Flavins with Diethyl Azodicarboxylate or Nitrosobenzene

Fumio Yoneda* and Yoshiharu Sakuma

*Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan


Treatment of 6-(N-alkylanilino)-5-aminouracils with diethyl azodicarboxylate or nitrosobenzene in ethanol or acetic acid in the indirect sunshine gave the correspond- ing flavins. The reaction mechanism has been definitely shown by the isolation of the key intermediates, 6-(N-alkylanilino)-5-iminouracils.