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Communication | Regular issue | Vol 6, No. 1, 1977, pp.19-23
Published online, 1st January, 1970
DOI: 10.3987/R-1977-01-0019
Picrohelein, a New Cytotoxic and Bitter Pseudoguaianolide from Sendai Helenium autumnale L

Yoshikazu Kondo,* Tsuyoshi Tomimori, Norio Hiraga, and Tsunematsu Takemoto

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Picrohelenin, a cytotoxic and intensely bitter pseudoguaianolide from the epigeal parts of Sendai Helenium autunnale L. (Compositae) has been established to be the structure I. The taste threshold of picrohelenin in man is 1.92 x 10-7 - 3.7 x 10-7 M. Picrohelenin proved to be inhibitory to tissue culture HeLa cells and its ID50 was 1.5 μg/ml.