Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 4, No. 11, 1976, pp.1777-1782
Published online, 1st January, 1970
DOI: 10.3987/R-1976-11-1777
Studies on the Synthesis of Bisindole Alkaloids. VII. Stereochemistry and Alternative Total Synthesis of Leurosine

James P. Kutney* and Brian R. Worth

*Department of Chemisry, University of British Columbia, Vancouver 8, V5T 1W5 , Canada


Polonovski-type coupling between 3β,4β-epoxy-3,4-dihydrocatharanthine-N-oxide and vindoline provides an alternative route to the anti-tumor agent leurosine. The previously questioned stereochemistry of the oxirane function of this bisindole alkaloid is determined unambiguously.