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Communication | Regular issue | Vol 4, No. 11, 1976, pp.1765-1770
Published online, 1st January, 1970
DOI: 10.3987/R-1976-11-1765
Reaction of 5-Nitrouracil Derivatives with Hydrazine and Potassium Cyanide

Shigeo Senda,* Kosaku Hirota, Tetsuji Asao, and Yoshihiro Yamada

*Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan

Abstract

Treatment of 5-nitro-1,3,6-trimethyluracil (I) with potassium cyanide or hydrazines gave 6-cyano-5- nitro-1,3,6-trimethyl-5,6-dihydrouracil (III) or 5-methyl-4-nitropyrazol-3-ones (IV), respectively. A treatment of 6-bromomethyl-1,3-dimethyl-5-nitrouracil (II) with potassium cyanide gave 6-cyano-1,3-dimethyl-5-nitrocyclothymine (V). Hydrazinolysis of II gave 1,3-dimethyluracil-6-carboxaldehyde hydrazones (VII).