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Report | Regular issue | Vol 4, No. 10, 1976, pp.1693-1698
Published online, 1st January, 1970
DOI: 10.3987/R-1976-10-1693
Reactions at C9 of Acridine Derivatives. XV. On the Mechanism of Hydrolysis of 1-Nitro-9-aminoacridines

Stanislaw Skonieczny* and Andrzej Ledochowski

*Laboratory of Chemistry and Biochemistry of Antitumour Compound, Institute of Organic and Food Chemistry and Technology, Techinical University of Gdansk, 80-952 Gdansk 6, Poland


The hydrolysis rate constants for 1-nitro-9-aminoacridines are dissimilar to those for other 9-aminoacridines. These differences are discussed in terms of 9-iminoacridan ⇔ 9-aminoacridine tautomerism existing in aqueous solutions.