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Communication | Regular issue | Vol 4, No. 10, 1976, pp.1681-1684
Published online, 1st January, 1970
DOI: 10.3987/R-1976-10-1681
Synthesis of Cardic Steroid 3-Suberoylbradykinin Esters

Youichi Fujii, Kazutaka Shimada, and Toshio Nambara*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


The cardiac steroid 3-suberoylbradykinin esters which may possibly occur in the toad venom, were synthesized by the activated ester method. Digitoxigenin 3-hemisuberate and bufotalin 3-hemisuberate were converted by the DCC method to the p-nitrophenyl esters, which in turn were condensed with bradykinin in aqueous pyridine to yield the desired compounds (1c, 2c).