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Communication | Regular issue | Vol 4, No. 10, 1976, pp.1645-1648
Published online, 1st January, 1970
DOI: 10.3987/R-1976-10-1645
Decarboxylation of Phenolic Tetrahydroisoquinolione-1-carboxylic Acids in Air

James M. Bobbitt,* Chidambar L. Kulkarni, and Pichaet Wiriyachitra

*Department of Chemistry, The University of Conneticut, Storrs, Conneticut 06268, U.S.A.


When stirred in air under basic conditions (NaHCO3, triethylamine, or NaOMe), tetrahydroisoquinoline-1-carboxylic acids containing at least one free phenol group in the aromatic ring decarboxylate oxidatively to yield 3,4-dihydroisoquinolines.