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Communication | Regular issue | Vol 4, No. 8, 1976, pp.1331-1335
Published online, 1st January, 1970
DOI: 10.3987/R-1976-08-1331
A New Alkylation of Pyridazines with Nitromethane and Nitroethane

Mitsuji Yanai,* Shigeko Takeda, and Makoto Nishikawa

*Faculty of Pharmaceutical Sciences, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan


3-Hydroxy-4-ethoxycarbonyl-6-chloropyridazine (I) reacts with nitromethane and nitroethane to give the respective 5-methyl (I-A) and 5-ethyl (I-B) derivatives when their solution in DMSO is stirred at room temperatures in the presence of potassium carbonate. The scope of this type of nuclear alkylation of pyridazines is rather wide as shown in Table.