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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Communication | Regular issue | Vol 4, No. 8, 1976, pp.1331-1335
Published online, 1st January, 1970■ A New Alkylation of Pyridazines with Nitromethane and Nitroethane
Published online, 1st January, 1970
DOI: 10.3987/R-1976-08-1331
■ A New Alkylation of Pyridazines with Nitromethane and Nitroethane
Mitsuji Yanai,* Shigeko Takeda, and Makoto Nishikawa
*Faculty of Pharmaceutical Sciences, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan
Abstract
3-Hydroxy-4-ethoxycarbonyl-6-chloropyridazine (I) reacts with nitromethane and nitroethane to give the respective 5-methyl (I-A) and 5-ethyl (I-B) derivatives when their solution in DMSO is stirred at room temperatures in the presence of potassium carbonate. The scope of this type of nuclear alkylation of pyridazines is rather wide as shown in Table.
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