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Communication | Regular issue | Vol 4, No. 5, 1976, pp.969-972
Published online, 1st January, 1970
DOI: 10.3987/R-1976-05-0969
Synthesis and Reduction of 2H-Cyclohepta[c]pyrrol-6-ones

R. Alan Jones* and Santokh Singh

*School of Chemical Sciences, University of East Anglia, Norwich, Northfolk NR4 7TJ, U.K.


The base catalysed condensation of 3,4-diformyl-2,5-dimethylpyrrole with propanone derivatives to give 2H-cyclohepta[c]pyrrol-6-ones is described. The reaction of the intermediate 1-(2,5-dimethyl-3-pyrrolyl)prop-1-en-3-ones with hydrazine yields 5,7-dimethyl-6H-pyrrolo[3,4-d]pyridazine. Catalytic hydrogenation of the 2H-cyclohept[c]pyrrol-6-ones produces the 4,5,7,8-tetrahydro ketones and the corresponding alcohols.