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Report | Regular issue | Vol 4, No. 2, 1976, pp.247-250
Published online, 1st January, 1970
DOI: 10.3987/R-1976-02-0247
A Total Synthesis of Naucléfine

Tetsuji Kametani,* Mitsuhiro Takeshita, and Masataka Ihara

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


A total synthesis of naucléfine (1) was accomplished by condensation of tryptamine with the lactone (16). prepared from nicotinonitrile (5), followed by cyclisation of the 7-azaisocarbostyril (8).