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Review | Regular issue | Vol 4, No. 1, 1976, pp.169-196
Published online, 1st January, 1970
DOI: 10.3987/R-1976-01-0169
Studies on Indole Alkaloid Biosynthesis. Part I. Alkaloids Containing the Normal Tryptophan Side Chain. The Later Stages

James P. Kutney*

*Department of Chemisry, University of British Columbia, Vancouver 8, V5T 1W5 , Canada


A summary of the experiments relating to the biosynthesis of various indole alklaoids and performed in the author’s laboratory is presented. The results as they relate to the later stages of the biosynthetic pathways in the Aspidosperma and Iboga bases are discussed in terms of the experiments performed in Catharanthus roseus G. Don (Vinca rosea L.) with the alkaloids vindoline and catharanthine. The plant, Vinca minor L., has been employed for obtaining some information about the eburnamine-vincamine series of alkaloids. The implications of these results and the remaining questions to be answered before definitive pathways can be proposed are also discussed.¡