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Report | Regular issue | Vol 4, No. 1, 1976, pp.47-50
Published online, 1st January, 1970
DOI: 10.3987/R-1976-01-0047
Synthtetic Studies on Mitomycins. An Alternative Synthesis of 2,3-Dihydro-1H and 9H-pyrrolo[1,2-a]indoles by Transannular Ring Closure

Tsuneo Itoh,* Toju Hata, and J. William Lown*

*School of Pharmaceutical Sciences, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, Japan

Abstract

The synthesis of substituted 1,2,3,4,5,6-hexahydro-2,3-benzazocin-5-ones and their conversion via trans-annular ring closure to the 2,3-dihydro-1H and 9H-pyrrolo[l,2-a]indole ABC parent ring system of the antitumor antibiotic mitomycin C is described.