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Communication | Regular issue | Vol 4, No. 1, 1976, pp.41-45
Published online, 1st January, 1970
DOI: 10.3987/R-1976-01-0041
Synthesis of a Fantastic Analgesic N-Cyclopropylmethyl-3-hydroxy-9-azamorphinan

Tetsuji Kametani,* Kazuo Kigawsawa, Mineharu Hiiragi, Nagatoshi Wagatsuma, Osamu Kusama, and Tsuneo Uryu

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Optical resolution of dl-N-cyclopropylmethyl-3-hydroxy-9-azamorphinan (I) was successfully effected with O,O-dibenzoyl-d-tartaric acid or (2R : 3R)-2’-nitrotartranilic acid as the result-ion agent. The optically active compounds thus obtained were tested for their analgesicactivity and antagonistic effect of morphine analgesia.