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Communication | Regular issue | Vol 4, No. 1, 1976, pp.23-28
Published online, 1st January, 1970
DOI: 10.3987/R-1976-01-0023
A One-step Synthesis of Evodiamine and Rutecarpine

Tetsuji Kametani,* Terumi Higa, Keiichiro Fukumoto, and Masuo Koizumi

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Evodiamine (1) and rutecarpine (2) were synthesised by condensation of 3,4-dihydro-β-carboline (5) with the keteneimines (6 and 12) derived from N-methylanthranilic acid (7) and anthranilic acid (10), respectively.