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Communication | Regular issue | Vol 3, No. 12, 1975, pp.1075-1079
Published online, 1st January, 1970
DOI: 10.3987/R-1975-12-1075
Studies on the Reactivity of Isoquinoline and Related Compounds. III. Addition Reaction of Acetic Anhydride with Isoquinoline and Phthalazine

Hiroshi Yamanaka,* Takayuki Shiraishi, and Takao Sakamoto

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


Addition of acetic anhydride to phthalazine and isoquinoline was investigated. The structures of the products were assigned 2-acetyl-1,2-dihydrophthalazine-1-acetic acid and 2-acetyl-1,2-dihydroisoquinoline-1-acetic acid, respectively. In the case of quinoline and quinoxaline this reaction did not occur.