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Communication | Regular issue | Vol 3, No. 8, 1975, pp.619-626
Published online, 1st January, 1970
DOI: 10.3987/R-1975-08-0619
Novel Formation of the Benzimidazo[2,1-a]isoquinoline and Benz[c]acridine from the 1,2,3,4-Tetrahydro-1-(2-nitrophenethyl)-isoquinoline with Triethyl Phosphite

Tetsuji Kametani,* Yasuo Fujimoto, and Masakatsu Mizushima

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Reductive cyclisation of 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4,5-dimethoxy-2-nitrophenethyl)isoquinoline (10) and its 2-methyl derivative (11) with triethyl phosphite gave 5,6-dihydro-2,3,9,10-tetramethoxybenzimidazo[2,1-a]isoquinoline (13) and 2,3,9,10- tetramethoxybenz[c]acridine (18), respectively.