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Communication | Regular issue | Vol 3, No. 7, 1975, pp.533-537
Published online, 1st January, 1970
DOI: 10.3987/R-1975-07-0533
A Novel Reaction of 3-Ethoxycarbonyl-2-methylthiothiazolo[2,3-a]isoquinolinium Sulfate with Active Methyl Compounds

Kazumichi Mizuyama, Yoko Matsuo, Yoshinori Tominaga, Yoshiro Matsuda, and Goro Kobayashi*

*Faculty of Pharmaceutical Sciences, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan


The reaction of 3-ethoxycarbonyl-2-methylthiothiazolo[2,3-a]isoquinolinium sulfate with active methyl compounds (nitromethane, acetophenone) in the presence of base produced ethyl 2-methylthio-1-nitropyrrolo[2,1-a]isoquinoline-3-carboxylate (II) and ethyl 2-methylthiopyrrolo[2,1-a]isoquinoline-3-carboxylate (III).