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Review | Regular issue | Vol 3, No. 4, 1975, pp.311-341
Published online, 1st January, 1970
DOI: 10.3987/R-1975-04-0311
Synthesis of the 1,2,3,4-Tetrahydroisoquinolines and Related Compounds by Phenolic Cyclisation

Tetsuji Kametani,* Keiichiro Fukumoto, Kazuo Kigasawa, Mineharu Hiiragi, and Haruhide Ishimaru

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


The new synthetic reaction of the 1-monosubstituted and 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines from 3-hydroxyphenethylamines and carbonyl compounds without an acidlc catalyst is described.