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Communication | Regular issue | Vol 3, No. 4, 1975, pp.287-291
Published online, 1st January, 1970
DOI: 10.3987/R-1975-04-0287
Reactions of Pyridine N-Oxide with Enamines of N-Substituted 4-Piperidones in the Presence of an Acylating Agent

Michio Nakanishi, Masahiro Yatabe, and Masatomo Hamana*

*Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

Abstract

Pyridine N-oxide reacts with enamines of N-benzoyl-, N-ethoxycarbonyl- and N-acetyl-4-piperidones in the presence of benzoyl chloride to give N-substituted 3-(2-pyridy1)-4-piperidones in fair or good yields. Enamine of N-methyl- or N-benzyl-4-piperidone resists this reaction.