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Communication | Regular issue | Vol 3, No. 3, 1975, pp.213-216
Published online, 1st January, 1970
DOI: 10.3987/R-1975-03-0213
Dealkylation of 1-sec-Alkyl-6-carbamoyl(or cyano)-3-methyluracils under Acidic Conditions

Shigeo Senda,* Kosaku Hirota, and Tetsuji Asao

*Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan


Hydrolysis of 1-sec-alkyl-6-carbamoyl-3-methyluracils in refluxing 48% hydrobromic acid causes dealkylation at the 1-position to give 3-methylorotic acid. Treatment of 1-sec-alkyl-6-carbamoyl(or cyano)-3-methyluracils in 98% H2SO4 afford 1-dealkylated 6-carbamoyl-1-methyluracils.