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Communication | Regular issue | Vol 3, No. 2, 1975, pp.123-128
Published online, 1st January, 1970
DOI: 10.3987/R-1975-02-0123
Chlorination of 1-Benzyl- or 1-Phenethyltetrahydroisoquinolines via a p-Quinol Acetate

Hiroshi Hara, Osamu Hoshino, and Bunsuke Umezawa*

*Faculty of Pharmaceutical Sciences, Science University of Tokyo, 2641 Yamazaki, Noda, Chiba 278-8510, Japan


Reaction of p-quinol acetates derived from 1-benzyl- (Ib and Ic) or 1-phenethyl- (Id, Ie and If) tetrahydroisoquinolines with conc. Hydrochloric acid gave the corresponding 8-chloro derivatives in fair yields.