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Communication | Regular issue | Vol 2, No. 5, 1974, pp.625-630
Published online, 1st January, 1970
DOI: 10.3987/R-1974-05-0625
Tetrahydroprotoberberines Derived from R- ans S-1-(3,4-Dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Sindey Teitel* and Jay P. O’Brien

*The Department of Chemistry Research, Hoffman-La Roghe Inc., Nutley, New Jersey 07110, U.S.A.


The syntheses of the optically-active diphenolic-substituted tetrahydroisoquinolines (5a,b), tetrahydropseudoberberines (7a,b), and tetrahydroprotoberberines (8a,b), all related to the anti-Parkinson agent apomorphine (1), are described. None exhibited dopamimetic activity.