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Communication | Regular issue | Vol 2, No. 5, 1974, pp.571-574
Published online, 1st January, 1970
DOI: 10.3987/R-1974-05-0571
Asymmetric Synthesis of Salsolidine

Tadashi Okawara and Tetsuji Kametani*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Optically active salsolidine (8) was isolated by reduction of 2-alkyl-3,4-dihydro-6,7-dimethoxy-l-methylisoquinolinium iodides (6) with sodium borohydride followed by hydrogenolysis of N-alkylsalsolidines (7) with 10 % palladium hydroxide on charcoal. The optical purities ranged from 15 to 44 %.