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Communication | Regular issue | Vol 2, No. 4, 1974, pp.457-460
Published online, 1st January, 1970
DOI: 10.3987/R-1974-04-0457
A Novel Synthesis of Pyrimidines. II. Cyclization of N-Cyano-cyanoacetamidines

Tadamasa Hirayama,* Masahiro Kamada, and Masataka Mimura

*Central Research Laboratoeies, Daiichi Pharmaceutical Co., Ltd., 16-13, Kitakasai 1-chome, Edsogawa-ku, Tokyo 134, Japan


Cyclization reaction of N-cyano-cyanoacetamidines (III) with hydrogen chloride and bromide has been found to give 4,6-diamino-2-halogenopyrimidines (IV), but with hydrogen iodide to give an unexpected 4-amino-6-iodopyrimidine (V).