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Communication | Regular issue | Vol 2, No. 3, 1974, pp.339-344
Published online, 1st January, 1970
DOI: 10.3987/R-1974-03-0339
A Facile Synthesis of the Spirobenzylisoquinolines and the Spirobenzylcarbolines

Tetsuji Kametani,* Yoshiro Hirai, Hiromitsu Takeda, Masahiro Kajiwara, Tamiko Takahashi, Fumio Satoh, and Keiichiro Fukumoto

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


1’,2,2’,3,3’,4’-Hexahydro-5,6,6’,7’-tetramethoxy-1-ketospiro[indene-2,1’-isoquinoline] (IVa) and its 7’-benzyloxy analogue (IVb) are synthesized from 3,4-dihydro-1-(4,5-dimethoxybenzocyclobutenyl)isoquinolines (I). 1-Ketospiro[indene-2,1’-β-carbolines] (XIa and XIb) are also obtained by the same method from the corresponding benzocyclobutene derivatives (IXa and IXb).