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Communication | Regular issue | Vol 1, No. 3, 1973, pp.223-226
Published online, 1st January, 1970
DOI: 10.3987/R-1973-03-0223
A Simple Synthesis of Isopavine Alkaloid, (±)-O-Methylthalisopavine and (±)-Reframine

Osamu Hoshino, Michinori Taga, and Bunsuke Umezawa*

*Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Funakawaramachi, Shinjuku-ku, Tokyo 162, Japan


(±)-O-Methylthalisopavine (I) and (±)-reframhe (II) were synthesized by acid treatment and subsequent methylation of (±)-4-acetoxytetrahydroisoquinoline [(V) and (VI)) directly derived from 6-hydroxytetrahydroisoquinoline [ (III) and (IV)].