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Paper | Special issue | Vol 52, No. 2, 2000, pp.661-666
Published online, 1st January, 1970
DOI: 10.3987/COM-99-S64
A Novel Synthesis of a Highly Sterically Hindered C2-Symmetric Chiral Pyridine Derivative

Hiyoshizo Kotsuki,*Hiromitsu Sakai, Jong-Gab Jun, and Motoo Shiro

*Department of Material Science, Faculty of Science, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan


A highly sterically hindered C2-symmetric chiral pyridine derivative (3) was synthesized from 1,5-diketone (2) by the action of NH4OAc/Cu(OAc)2 in refluxing propionic acid. The pKa of 3 was determined to be 6.26 and the structure was characterized by X-Ray crystallographic analysis of its triflic acid salt.