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Communication | Special issue | Vol 52, No. 3, 2000, pp.1037-1040
Published online, 1st January, 1970
DOI: 10.3987/COM-99-S125
Scandium Triflate Catalyzed Formation of Benzothiazole from 2-Aminobenzenethiol and Formaldehyde in the Presence of Water

Takashi Itoh, Kazuhiro Nagata, Michiko Miyazaki, and Akio Ohsawa*

*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

Abstract

In the presence of a catalytic amount of scandium triflate, 2-aminobenzenethiol and formaldehyde in water reacted to give an imine, followed by ring closure to afford a thiazoline, which was aromatized by oxygen or DDQ to give a high yield of benzothiazole.