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Communication | Special issue | Vol 52, No. 2, 2000, pp.587-590
Published online, 1st January, 1970
DOI: 10.3987/COM-99-S107
A Novel Synthesis of Avermectin B1a from Avermectin B2a

Tadashi Katoh,* Etsuko Itoh, and Shiro Terashima*

*Sagami Central Research Center, Nishi-Ohnuma, Sagamihara, Kanagawa 229-0012, Japan

Abstract

The title synthesis was achieved via a four-step sequence of reactions including selective silylation of the C4”- and the C5-hydroxy groups, mesylation of the remaining C23-hydroxy group, tetra-n-butylammonium oxalate-induced elimination, and deprotection of the silyl protecting groups.