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Communication | Regular issue | Vol 53, No. 4, 2000, pp.765-770
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8818
Convenient Synthesis of a 2,3,6-Tristhiazolylsubstituted Pyridine Skeleton [Fragment A-C] of a Macrocyclic Antibiotic, GE 2270 A

Kazuo Okumura, Taishi Suzuki, and Chung-gi Shin*

*Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa University, Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan

Abstract

Convenient synthesis of the 2,3,6-tristhiazolylsubstituted pyridine skeleton [Fragment A-C] of a macrocyclic antibiotic, GE 2270 A, was first achieved from a chiral 2-(2-{2-[(1R,2S)-(1-amino-2-hydroxy-2-phenyl)ethyl]-thiazol-4-yl}thiazol-4-yl)pyridine derivative [Fragment A] and H-L-Ser-L-Pro-NH2 as the precursor of Fragment C.