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Paper | Regular issue | Vol 53, No. 4, 2000, pp.797-804
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8814
Synthesis of 4-[4’-(N,N-Dimethylsulfamoyl)piperazin-1-yl]pyridine Derivatives as Sorbitol Dehydrogenase Potential Inhibitors

Didier Varlet, Eric Fourmaintraux, Patrick Depreux, and Daniel Lesieur*

*Institut de Chimie Pharmaceutiqe, Université de Lille 2, rue du Professeur Laguesse, 59006 Lille, France


A synthesis of various pyridines disubstituted in position 4 by a [4’-(N,N-dimethylsulfamoyl)piperazin-1-yl] group and in position 2 by different functionalities such as hydrogen, hydroxymethyl, formyl, carboxamido or cyano, is described.