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Note | Regular issue | Vol 53, No. 3, 2000, pp.733-737
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8813
Short Step Synthesis of (4R)-4-Hydroxymethyl-4-methyl-2-hexene-1,5-diol: A Useful Chiral Synthon for Natural Product Synthesis with Quaternary Carbon Center

Kunisuke Okada,* Daisuke Nakamura, and Yuhji Hattori

*Faculty of Pharmacy, Meijo University, Tenpaku, Nagoya 468-8503, Japan


A chiral synthon (2), prepared previously via 1,2-acyl migration of the optically active α,β-epoxy ketone (1), was synthesized from Koga’s chiral keto ester (6) in 4 steps.