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Paper | Regular issue | Vol 53, No. 3, 2000, pp.613-620
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8784
Synthesis and Structural Features of New Cyclofunctionalized Benzimidazoles

Alba Chimirri,* Anna Maria Monforte, Pietro Monforte, Francesco Nicolò, Angela Rao, and Maria Zappalà

*Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy

Abstract

The synthesis of new tricyclic derivatives having sulfur-containing six or seven-membered rings fused to the «a» edge of benzimidazole system, is reported. The stereochemical characteristics of thiazino- and thiazepinobenzimidazoles (4-7) are described and comparative NMR data are discussed. The synthetic approach to new benzo- or pyridothiazinobenzimidazole tetracyclic systems (8) is also reported.