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Paper | Regular issue | Vol 53, No. 2, 2000, pp.347-351
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8780
A Novel Ring Closure Reaction for the Preparation of 6-Aminouracils with an α-Branched 1-Substituent

Friederike Fülle and Christa E. Müller*

*Pharmazeutishes Institut, Pharmazeutische Chemie Poppelsdorf, Universität Bonn, Kreuzbergweg 26, D-53115 Bonn, Germany


The preparation of 6-aminouracil derivatives is described involving a novel, silicon-promoted ring closure reaction. Condensation of N-substituted urea with cyanoacetic acid yields cyanoacetylureas, which are heated in hexamethyldisilazane/trimethylchlorosilane to afford N-substituted 6-aminouracils. Previously unaccessible derivatives bearing an α-branched 1-substituent, including 6-amino-1-(1-phenylethyl)uracil were obtained.