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Paper | Regular issue | Vol 53, No. 2, 2000, pp.339-346
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8775
Transformations of (S )-1-Acyl-3-[(E )-(dimethylamino)methylidene]-5-(methoxycarbonyl)pyrrolidin-2-ones. A One-Step Synthesis of (S)-N -Benzoyl-3-(1-heteroaryl-5-hydroxy-1H -pyrazolyl-4)alanine Esters

Marko Skof, Jurij Svete,* and Branko Stanovnik*

*Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, 1000 Ljubljana, Slovenia


(S)-1-Benzoyl-3-[(E)-(dimethylamino)methylidene]-5-(methoxycarbonyl)pyrrolidin-2-one (1) and (S)-1-tert-butoxycarbonyl-3-[(E)-(dimethylamino)methylidene]-5-(methoxy-carbonyl)pyrrolidin-2-one (2) were transformed in one step with various hydrazines (3-10) into the corresponding (S)-3-(1-substituted 5-hydroxy-1H-pyrazolyl-4)alanine methyl esters (11-19).