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Note | Regular issue | Vol 53, No. 3, 2000, pp.675-679
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8761
Gaulthrins C and D, Two New Lignans from the Roots of Gaultheria yunnanensis

Zhizhen Zhang, Dean Guo,* Junhua Zheng, Kazuo Koike, Zhonghua Jia, and Tamotsu Nikaido

*School of Pharamceutical Sciences, Beijing Medical University, Beijing, 100083, China


Two new lignans, designated as gaultherins C (1) and D (2), were isolated from roots of Gaultheria yunnanensis. Their stuctures were determined as 1,3,3aα,4α,9,9aβ-hexahydro-4-(4-hydroxy-3,5-dimethoxyphyenyl )-5,7-dimethoxynaphtho[2,3-c]furan-6-ol (1) and 1,3,3aα,4α,9,9aβ-hexahydro-4-(4- hydroxy-3,5-dimethoxyphenyl)-7-methoxynaphtho[2,3-c]furan-6-ol(2) based on the physico-chemical properties and the extensive NMR (DEPT, DQF-COSY, HETCOR, phase-sensitive NOESY, and HMBC experiinents) studies.