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■ An Expeditious Synthesis of Pyrrolo[3,4-d]pyrimidine-2,4-dione from Uracil

Michael N. Zimmerman, Norman H. Nemeroff, Charles W. Bock, and Krishna L. Bhat*

*Department of Chemistry, School of Science and Health, Philadelphia University, Philadelphia, PA 19144, U.S.A.

Abstract

An efficient, practical and cost effective synthesis of the title compound has been realized from uracil. The key step is the construction of the pyrrole ring using tosylmethylisocyanide (TosMIC) methodology. The structure of uracil, reaction intermediates and the final product were investigated using density functional calculations.