Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 53, No. 1, 2000, pp.205-211
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8732
An Expeditious Synthesis of Pyrrolo[3,4-d]pyrimidine-2,4-dione from Uracil

Michael N. Zimmerman, Norman H. Nemeroff, Charles W. Bock, and Krishna L. Bhat*

*Department of Chemistry, School of Science and Health, Philadelphia University, Philadelphia, PA 19144, U.S.A.


An efficient, practical and cost effective synthesis of the title compound has been realized from uracil. The key step is the construction of the pyrrole ring using tosylmethylisocyanide (TosMIC) methodology. The structure of uracil, reaction intermediates and the final product were investigated using density functional calculations.