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Note | Regular issue | Vol 53, No. 1, 2000, pp.197-204
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8730
Regioselective Aminomethylations of Bicyclic Phenols

Jos Lange,* Sonja Hoogeveen, Willem Veerman, and Henri Wals

*Solvay Pharmaceuticals Research Laboratpries, Medicinal Chemistry Department, P. O. Box 900, 1380 DA Weesp, The Netherlands


The regioselectivity in the aminomethylations (the Mannich reaction) of bicyclic phenols has been studied. Highly regioselective Mannich reactions enable easy synthetic access to novel bicyclic dialkylaminomethylphenols under very mild reaction conditions.