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Note | Regular issue | Vol 53, No. 1, 2000, pp.191-195
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8722
5-Butyl-3,5-diaryl-4,5-dihydro-1,2,4-oxadiazoles, and a One-Step Synthesis of 4,4-Dibutyl-2-phenylbenzo-1,3-oxazine

Rajendra M. Srivastava,* Maurício F. Rosa, Carlos Eduardo M. Carvalho, Samira da G. M. Portugal, Ira M. Brinn, Maria da Conceição Pereira, and Octávio A. C. Antunes

*Departamento de Química Fundamental, Universidade Federal de Pernambuco, Cidade Universitária, 50.740-540 Recife, PE, Brazil


The synthesis of 5-butyl-3,5-diaryl-4,5-dihydro-1,2,4-oxadiazoles is described. The present work also describes the discovery of a reaction leading to the conversion of 5-butyl-5-(2-hydroxyphenyl)-3-phenyl-4,5-dihydro-1,2,4-oxadiazole (1d) to 4,4-dibutyl-2-phenylbenzo-1,3-oxazine (3).