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Paper | Regular issue | Vol 51, No. 10, 1999, pp.2377-2384
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8629
A Synthesis of 4-Quinolone-3-carboxylic Acids via Pyrolysis of N-Aryldioxopyrrolines

Kunihiko Mohri,* Akihiko Kanie, Yoshie Horiguchi, and Kimiaki Isobe

*Showa College of Pharmaceutical Sciences, 3-3165, Higashi-tamagawagakuen, Machida, Tokyo 194-8543, Japan

Abstract

A synthesis of 4-quinolone-3-carboxylic acids (8) was achieved by pyrolysis of 4,5-dimethoxycarbonyl-1-aryl-1H-pyrrole-2,3-diones (3) followed by selective de-methoxycarbonylation of the resulting 2,3-dimethoxycarbonyl-4-quinolones (4) in excellent overall yields.