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Paper | Regular issue | Vol 51, No. 9, 1999, pp.2127-2137
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8626
Synthesis of 6-Substituted 5,6,7,12-Tetrahydrobenzo[4,5]cyclohept[b]indol-12-one Derivatives

Abderrahim Mouaddib, Benoît Joseph, Aissa Hasnaoui, Jean-Yves Mérour,* and Stéphane Léonce

*Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, BP 6759, Rue de Chartres, 45067 Orléans Cédex 2, France


The synthesis of 6-substituted 5,6,7,12-dihydrobenzo[4,5]cyclohept[b]indole derivatives, through a regioselective alkylation of 1 in position-6, is reported. The antiproliferative activity of 18 was evaluated.