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Note | Regular issue | Vol 51, No. 8, 1999, pp.1949-1956
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8608
Nucleophilic Substitution Reaction of 3-Acetyl-1-methoxyindole and Its Application for the Synthesis of Novel 2-Substituted Methyl 2,3-Dihydro-1-methyl-3-oxo-5H-pyrido[4,3-b]indole-4-carboxylates

Masanori Somei,* Masahiro Nakajou, Tsuyoshi Teramoto, Asuka Tanimoto, and Fumio Yamada

*Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


A simple synthetic route was established for 3-acetyl-1-methoxyindole, which was found to undergo nucleophilic substitution reactions selectively at the 2-position. Applying the reaction, novel 2-substituted methyl 2,3-dihydro-1-methyl-3-oxo-5H-pyrido[4,3-b]indole-4-carboxylates were prepared.